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Anxiety with depression ICD-10 code

Published September 25, 2025

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Searching for the anxiety with depression ICD-10 code?

To support private practice clinicians and administrative staff in identifying the right code to use in patient records and billing, this article provides an overview of the anxiety with depression ICD-10 code, including the diagnostic criteria, differential diagnoses, and anxiety with depression coding guidelines. 

We also address if there is a mixed anxiety with depression ICD-10 code and how to record a depression with anxiety ICD-10 code. 

Bookmark this article as a reference to use next time you need to access the most common diagnostic codes for anxiety and depression.

What is the ICD-10?

Therapists use ICD-10 codes to assist with diagnosis and treatment planning. 

Using the right ICD codes also avoids unnecessary delays with insurance companies. 

However, it can be challenging to keep track of every single diagnosis code, especially with regular revisions of diagnostic and coding information. 

To help, we’ve created a list of the most frequently used ICD-10 codes.

The International Classification of Diseases, Tenth Revision (ICD-10) is a guide published by the World Health Organization (WHO) that allows clinicians around the world to use standard diagnostic language. 

In the United States, clinicians use a version called the ICD-10-CM, which stands for clinical modification. The U.S. Department of Health and Human Services developed the CM version with permission from the WHO, expanding some codes and combining others.

Behavioral health practitioners in the U.S. also use the American Psychiatric Association’s (APA) Diagnostic and Statistical Manual of Mental Health Disorders, Fifth Edition (DSM-5), for diagnostic criteria and clinical guidance. The DSM-5 includes the corresponding ICD-10-CM codes for each mental health diagnosis.

For example, in the DSM-5, you’ll be able to find the anxiety with depression ICD-10 code and its diagnostic criteria. 

Using this standardized coding system allows clinicians and statisticians to better measure and track health information, enabling greater specificity in identifying health conditions.


What is the anxiety with depression ICD-10 code?

ICD-10 codes are used to record diagnoses, accompany assessments, and bill insurance payers. 

Mental health and behavioral disorder codes begin with the letter "F."

Depressive disorders are listed in the ICD-10-CM under section F30-F39 "Mood [affective] disorders," alongside bipolar and related disorders. Anxiety disorders fall under section F40-F48 "Anxiety, dissociative, stress-related, somatoform and other nonpsychotic mental disorders."

While it is considered best practice among clinicians to code separate diagnoses for each condition, there may be instances when one anxiety with depression ICD-10 code is used.

This includes:

  • F43.23 - Adjustment disorder with mixed anxiety and depressed mood: Used when both anxiety and depression arise from an identifiable stressor and don't meet criteria for separate major mental disorders.

  • F41.8 - Other specified anxiety disorders: Used when anxiety symptoms cause clinically significant distress or impairment but don't meet full criteria for a specific anxiety disorder, requiring the clinician to specify the particular presentation.

Important note: Unlike the international ICD-10, the U.S. version (ICD-10-CM) does not include F41.2 (mixed anxiety with depression ICD-10) as this is not considered a valid diagnosis in American clinical practice. 

Diagnostic criteria for anxiety with depression

The ICD-10-CM and DSM-5 do not include F41.2 (mixed anxiety and depression ICD-10 code). 

Rather than using one anxiety with depression ICD-10 code, when anxiety and depression are both present, they should typically be coded as separate diagnoses.

Code F41.8 (other specified anxiety disorders) may be used for anxiety presentations that cause clinically significant distress and impairment, but don't meet full criteria for specific anxiety disorders.

When using F41.8, clinicians must specify the particular presentation, such as:

  • Generalized anxiety occurring less frequently than "more days than not"

  • Limited-symptom panic attacks

  • Anxiety symptoms that are situational but don't meet adjustment disorder criteria

Note: F41.8 is not specifically intended for mixed anxiety-depression presentations. When both conditions are present and meet diagnostic criteria, separate codes should be used instead of one mixed anxiety with depression ICD-10 code.


Other common anxiety and depression ICD-10 codes

Some common anxiety and depression ICD codes include:

  • F41.0: Panic disorder

  • F41.1: Generalized anxiety disorder

  • F41.3: Other mixed anxiety disorders

  • F41.8: Other specified anxiety disorders

  • F41.9: Anxiety disorder, unspecified

  • F43.22: Adjustment disorder with anxiety

  • F43.21: Adjustment disorder with depressed mood

  • F33.0: Major depressive disorder, recurrent, mild

  • F33.1: Major depressive disorder, recurrent, moderate

  • F33.2: Major depressive disorder, recurrent severe without psychotic features

  • F32.1: Major depressive disorder, single episode, moderate

  • F32.9: Major depressive disorder, single episode, unspecified

You can find more diagnosis codes in our article: The 20 most-frequently billed ICD-10 codes.

Differential diagnoses

Even though clients may meet some criteria for other specified anxiety disorder, or adjustment disorder with anxiety and depression, there may be a more appropriate diagnosis, such as:

  • Unspecified anxiety disorder

  • Normative stress reactions

  • Personality disorders

  • Bereavement

  • Major depressive disorder

  • Social anxiety disorder

  • Agoraphobia

  • Separation anxiety disorder

  • Panic disorder

  • Obsessive-compulsive disorder

  • Eating disorders

  • Schizophrenia spectrum and psychotic disorders

  • Trauma-and-stressor-related disorders

  • Psychological factors affecting other medical conditions

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